| Date | Location | Result | |
| 03/10/22 | Las Vegas, Nev. | California Baptist 85, Sam Houston 78 | Box score |
| 03/09/22 | Las Vegas, Nev. | Sam Houston 73, Lamar 69 | Box score |
| 03/02/22 | Stephenville, Texas | Tarleton 83, Sam Houston 63 | Box score |
| 02/26/22 | Huntsville, Texas | Sam Houston 69, Grand Canyon 66 | Box score |
| 02/24/22 | Huntsville, Texas | Stephen F. Austin 73, Sam Houston 58 | Box score |
| 02/19/22 | Huntsville, Texas | Sam Houston 69, UTRGV 49 | Box score |
| 02/17/22 | Abilene, Texas | Abilene Christian 88, Sam Houston 71 | Box score |
| 02/14/22 | Beaumont, Texas | Sam Houston 66, Lamar 57 | Box score |
| 02/12/22 | Huntsville, Texas | Sam Houston 61, Chicago State 58 | Box score |
| 02/05/22 | Orem, Utah | Sam Houston 69, Utah Valley 66 | Box score |
| 02/03/22 | St. George, Utah | Sam Houston 74, Dixie State 72 (OT) | Box score |
| 01/29/22 | Huntsville, Texas | Sam Houston 73, Seattle U 54 | Box score |
| 01/27/22 | Huntsville, Texas | Sam Houston 73, California Baptist 65 | Box score |
| 01/24/22 | Edinburg, Texas | Sam Houston 66, UTRGV 52 | Box score |
| 01/22/22 | Phoenix, Ariz. | Grand Canyon 73, Sam Houston 54 | Box score |
| 01/20/22 | Las Cruces, N.M. | New Mexico State 72, Sam Houston 59 | Box score |
| 01/17/22 | Huntsville, Texas | Tarleton 62, Sam Houston 61 | Box score |
| 01/15/22 | Nacogdoches, Texas | Stephen F. Austin 79, Sam Houston 46 | Box score |
| 01/13/22 | Huntsville, Texas | Lamar 68, Sam Houston 55 | Box score |
| 01/08/22 | Huntsville, Texas | Abilene Christian 70, Sam Houston 59 | Box score |
| 12/20/21 | Huntsville, Texas | Sam Houston 132, Arlington Baptist 55 | Box score |
| 12/16/21 | Huntsville, Texas | Rice 74, Sam Houston 64 | Box score |
| 12/13/21 | Tuscaloosa, Ala. | Alabama 84, Sam Houston 50 | Box score |
| 12/10/21 | Ruston, La. | Louisiana Tech 77, Sam Houston 52 | Box score |
| 11/30/21 | Huntsville, Texas | Sam Houston 66, Longwood 65 | Box score |
| 11/27/21 | Fayetteville, Ark. | Arkansas 92, Sam Houston 66 | Box score |
| 11/20/21 | Huntsville, Texas | Sam Houston 88, Hartford 65 | Box score |
| 11/17/21 | Huntsville, Texas | Sam Houston 88, USAO 73 | Box score |
| 11/15/21 | Tulsa, Okla. | Tulsa 64, Sam Houston 48 | Box score |
| 11/13/21 | Arlington, Texas | UT Arlington 72, Sam Houston 54 | Box score |
| 11/11/21 | Huntsville, Texas | Sam Houston 86, Wiley 62 | Box score |